منابع مشابه
Distinct G protein–coupled receptor recycling pathways allow spatial control of downstream G protein signaling
G protein-coupled receptors (GPCRs) are recycled via a sequence-dependent pathway that is spatially and biochemically distinct from bulk recycling. Why there are two distinct recycling pathways from the endosome is a fundamental question in cell biology. In this study, we show that the separation of these two pathways is essential for normal spatial encoding of GPCR signaling. The prototypical ...
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Text by Mitch Leslie [email protected] Diet ing yeast c lean house W hen a yeast cell hunkers down for hard times, it kicks its proteasomes out of the nucleus, as Laporte et al. show. The cell’s garbage disposal, the proteasome, digests proteins that are damaged or no longer needed. In dividing yeast, proteasomes in the nucleus help drive the cell cycle by demolishing regulatory proteins ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2010
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2010.184